{"id":2897598,"date":"2026-11-02T12:55:56","date_gmt":"2026-11-02T10:55:56","guid":{"rendered":"https:\/\/eportal.gr\/portal\/?p=2897598"},"modified":"2026-11-02T12:55:56","modified_gmt":"2026-11-02T10:55:56","slug":"esmo-2026-%ce%bf%ce%b9-%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b5%cf%82-%cf%80%ce%bf%cf%85-%ce%b1%ce%bb%ce%bb%ce%ac%ce%b6%ce%bf%cf%85%ce%bd-%cf%84%ce%bf%ce%bd-%ce%ba%ce%b1%cf%81%ce%ba%ce%af","status":"publish","type":"post","link":"https:\/\/eportal.gr\/portal\/esmo-2026-%ce%bf%ce%b9-%ce%b8%ce%b5%cf%81%ce%b1%cf%80%ce%b5%ce%af%ce%b5%cf%82-%cf%80%ce%bf%cf%85-%ce%b1%ce%bb%ce%bb%ce%ac%ce%b6%ce%bf%cf%85%ce%bd-%cf%84%ce%bf%ce%bd-%ce%ba%ce%b1%cf%81%ce%ba%ce%af\/","title":{"rendered":"ESMO 2026: \u039f\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf"},"content":{"rendered":"<p> \n<\/p>\n<div>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">\u03a4\u03bf \u03b5\u03c4\u03ae\u03c3\u03b9\u03bf \u03c3\u03c5\u03bd\u03ad\u03b4\u03c1\u03b9\u03bf \u03c4\u03b7\u03c2 \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ae\u03c2 \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 (ESMO 2026), \u03c0\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7 \u039c\u03b1\u03b4\u03c1\u03af\u03c4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 23 \u03ad\u03c9\u03c2 \u03c4\u03b9\u03c2 27 \u039f\u03ba\u03c4\u03c9\u03b2\u03c1\u03af\u03bf\u03c5, \u03b4\u03b5\u03bd \u03ae\u03c4\u03b1\u03bd \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bc\u03b9\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03c5\u03bd\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03cc\u03bd\u03c9\u03bd. \u0389\u03c4\u03b1\u03bd \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03b8\u03b5\u03c9\u03c1\u03af\u03b1 \u03c3\u03c5\u03bd\u03ac\u03bd\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c0\u03bf\u03c5 \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 3 \u03ae\u03c1\u03b8\u03b1\u03bd \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b5\u03c1\u03c9\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 \u03c4\u03b1\u03bb\u03ac\u03bd\u03b9\u03b6\u03b1\u03bd \u03c4\u03b7\u03bd \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03ba\u03bf\u03b9\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1. \u03a4\u03bf \u03bc\u03ae\u03bd\u03c5\u03bc\u03b1 \u03ae\u03c4\u03b1\u03bd \u03c3\u03b1\u03c6\u03ad\u03c2: \u03b7 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b4\u03b5\u03bd \u03b5\u03be\u03b5\u03bb\u03af\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b5\u03cd\u03b8\u03c5\u03bd\u03c3\u03b7 \u03c4\u03c9\u03bd \u00ab\u03bd\u03ad\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd\u00bb, \u03b1\u03bb\u03bb\u03ac \u03c0\u03c1\u03bf\u03c2 \u03bc\u03b9\u03b1 <\/span><strong><span class=\"\">\u03c0\u03b9\u03bf \u03ad\u03be\u03c5\u03c0\u03bd\u03b7, \u03c0\u03b9\u03bf \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03c0\u03b9\u03bf \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7<\/span><\/strong><span class=\"\"> \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5. \u0391\u03c0\u03cc \u03c4\u03b1 \u03c0\u03c1\u03ce\u03c4\u03b1 \u03b8\u03b5\u03c4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03bd\u03cc\u03c2 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b5\u03bc\u03b2\u03bf\u03bb\u03af\u03bf\u03c5 mRNA \u03ad\u03c9\u03c2 \u03bd\u03ad\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03c4\u03bf ESMO 2026 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b5\u03af \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03b5\u03c0\u03bf\u03c7\u03ae.<\/span><\/p>\n<h3><span class=\"\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1: \u03a4\u03c1\u03af\u03b1 \u00ab\u03c7\u03c4\u03c5\u03c0\u03ae\u03bc\u03b1\u03c4\u03b1\u00bb \u03c0\u03bf\u03c5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">\u039f \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf\u03c5\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b5\u03b4\u03c1\u03af\u03bf\u03c5, \u03bc\u03b5 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bd\u03ad\u03b4\u03b5\u03b9\u03be\u03b1\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">\u039c\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 (SCLC): \u03a4\u03bf tarlatamab \u03c6\u03ad\u03c1\u03bd\u03b5\u03b9 \u03b5\u03c0\u03b1\u03bd\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7<\/span><\/strong><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">\u039f \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf \u03b5\u03b4\u03ce \u03ba\u03b1\u03b9 \u03b4\u03b5\u03ba\u03b1\u03b5\u03c4\u03af\u03b5\u03c2. \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 <\/span><strong><span class=\"\">DeLLphi-305<\/span><\/strong><span class=\"\"> \u03ae\u03c1\u03b8\u03b5 \u03bd\u03b1 \u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1. \u0397 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c4\u03bf\u03c5 <\/span><strong><span class=\"\">tarlatamab<\/span><\/strong><span class=\"\"> (\u03b5\u03bd\u03cc\u03c2 \u03b1\u03bc\u03c6\u03b9\u03b5\u03b9\u03b4\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b1 CD3 \u03ba\u03b1\u03b9 DLL3) \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03c5\u03bd\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7\u03c2 \u03bc\u03b5 <\/span><strong><span class=\"\">durvalumab<\/span><\/strong><span class=\"\">, \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7\u03bd \u03b1\u03c1\u03c7\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, <\/span><strong><span class=\"\">\u03b1\u03cd\u03be\u03b7\u03c3\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc 12,7 \u03c3\u03b5 21,1 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/strong><span class=\"\"> \u2014 \u03bc\u03b9\u03b1 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03ac <\/span><strong><span class=\"\">8,4 \u03bc\u03b7\u03bd\u03ce\u03bd<\/span><\/strong><span class=\"\"> \u2014 \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03cc \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac <\/span><strong><span class=\"\">58%<\/span><\/strong><span class=\"\"> (HR 0,42)<\/span><span class=\"\">. \u0397 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ae\u03c4\u03b1\u03bd <\/span><strong><span class=\"\">7,4 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/strong><span class=\"\"> \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 <\/span><strong><span class=\"\">1,9 \u03bc\u03b7\u03bd\u03ce\u03bd<\/span><\/strong><span class=\"\"> \u03bc\u03b5 \u03c4\u03b7 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 durvalumab (HR 0,34)<\/span><span class=\"\">. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c0\u03bf\u03c5, \u03cc\u03c0\u03c9\u03c2 \u03c3\u03b7\u03bc\u03b5\u03af\u03c9\u03c3\u03b1\u03bd \u03bf\u03b9 \u03b5\u03c1\u03b5\u03c5\u03bd\u03b7\u03c4\u03ad\u03c2, \u03b5\u03af\u03bd\u03b1\u03b9 <\/span><strong><span class=\"\">\u03c3\u03c0\u03ac\u03bd\u03b9\u03bf<\/span><\/strong><span class=\"\"> \u03b3\u03b9\u03b1 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7\u03bd \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03af\u03b3\u03b5\u03b9 \u03bd\u03ad\u03bf\u03c5\u03c2 \u03b4\u03c1\u03cc\u03bc\u03bf\u03c5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 SCLC.<\/span><\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">\u039c\u03b7 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 (NSCLC): \u03a4\u03bf divarasib \u03c5\u03c0\u03b5\u03c1\u03ad\u03c7\u03b5\u03b9 \u03c4\u03c9\u03bd \u03c5\u03c0\u03b1\u03c1\u03c7\u03cc\u03bd\u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd KRAS<\/span><\/strong><\/p>\n<p>\u03a3\u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf NSCLC \u03bc\u03b5 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 KRAS G12C, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 KRASCENDO-1 \u03c3\u03c5\u03bd\u03ad\u03ba\u03c1\u03b9\u03bd\u03b5 \u03c4\u03bf \u03bd\u03ad\u03bf divarasib \u03bc\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03ac\u03c1\u03c7\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 sotorasib \u03ae adagrasib. \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b5\u03bd\u03c4\u03c5\u03c0\u03c9\u03c3\u03b9\u03b1\u03ba\u03ac: \u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc 12,0 \u03c3\u03b5 17,7 \u03bc\u03ae\u03bd\u03b5\u03c2 (HR 0,56, p=0,0005), \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03b1\u03c0\u03cc 5,7 \u03c3\u03b5 9,8 \u03bc\u03ae\u03bd\u03b5\u03c2 (HR 0,58). \u03a4\u03bf divarasib \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03c0\u03c1\u03bf\u03c6\u03af\u03bb \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03c0\u03c1\u03bf\u03ba\u03b1\u03c4\u03cc\u03c7\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5, \u03b8\u03ad\u03c4\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bd\u03ad\u03b1 \u03c0\u03c1\u03cc\u03c4\u03c5\u03c0\u03b1 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c5\u03c0\u03bf\u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">NSCLC \u03bc\u03b5 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 EGFR: \u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 osimertinib + savolitinib<\/span><\/strong><\/p>\n<p>\u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 SAFFRON \u03b5\u03be\u03ad\u03c4\u03b1\u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 EGFR-\u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03b1\u03b3\u03bc\u03ad\u03bd\u03bf NSCLC \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b1\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c5\u03c0\u03cc osimertinib \u03ba\u03b1\u03b9 \u03b5\u03af\u03c7\u03b1\u03bd \u03c5\u03c8\u03b7\u03bb\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03ae \u03b5\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 MET. \u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 osimertinib + savolitinib \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b5 \u03c4\u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03b1\u03c0\u03cc 12,9 \u03c3\u03b5 17,8 \u03bc\u03ae\u03bd\u03b5\u03c2 (HR 0,68) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03b1\u03c0\u03cc 5,4 \u03c3\u03b5 7,6 \u03bc\u03ae\u03bd\u03b5\u03c2 (HR 0,55). \u03a4\u03bf \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5 \u03c3\u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5, \u03ce\u03c3\u03c4\u03b5 \u03bd\u03b1 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bf\u03b9 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03af \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03c0\u03b9\u03bb\u03ad\u03b3\u03b5\u03c4\u03b1\u03b9 \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c0\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1.<\/p>\n<h3><span class=\"\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5: \u03a4\u03bf sonesitatug vedotin \u00ab\u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03b6\u03b5\u03b9\u00bb \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03b7 \u03bd\u03cc\u03c3\u03bf<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">\u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 <\/span><strong><span class=\"\">CLARITY-Gastric01<\/span><\/strong><span class=\"\"> \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1\u03c3\u03b5 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 <\/span><strong><span class=\"\">sonesitatug vedotin<\/span><\/strong><span class=\"\">, \u03b5\u03bd\u03cc\u03c2 \u03bd\u03ad\u03bf\u03c5 \u03c3\u03c5\u03b6\u03b5\u03c5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2-\u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03bf\u03c5 (ADC) \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 <\/span><strong><span class=\"\">CLDN18.2<\/span><\/strong><span class=\"\">. \u03a3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5 \u03ae \u03b3\u03b1\u03c3\u03c4\u03c1\u03bf\u03bf\u03b9\u03c3\u03bf\u03c6\u03b1\u03b3\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c5\u03bc\u03b2\u03bf\u03bb\u03ae\u03c2 \u03c0\u03bf\u03c5 \u03b5\u03af\u03c7\u03b1\u03bd \u03bb\u03ac\u03b2\u03b5\u03b9 \u03c0\u03c1\u03bf\u03b7\u03b3\u03bf\u03cd\u03bc\u03b5\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2, \u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc <\/span><strong><span class=\"\">6,4 \u03c3\u03b5 10,6 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/strong><span class=\"\"> (HR 0,58), \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac <\/span><strong><span class=\"\">42%<\/span><\/strong><span class=\"\">. \u03a4\u03bf \u03c0\u03b9\u03bf \u03b5\u03bd\u03c4\u03c5\u03c0\u03c9\u03c3\u03b9\u03b1\u03ba\u03cc \u03b5\u03cd\u03c1\u03b7\u03bc\u03b1 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd <\/span><strong><span class=\"\">\u03c4\u03c1\u03af\u03c4\u03b7 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03ac<\/span><\/strong><span class=\"\">, \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 <\/span><strong><span class=\"\">\u03b4\u03b9\u03c0\u03bb\u03b1\u03c3\u03b9\u03ac\u03c3\u03c4\u03b7\u03ba\u03b5<\/span><\/strong><span class=\"\"> \u2014 \u03b1\u03c0\u03cc <\/span><strong><span class=\"\">5,0 \u03c3\u03b5 10,0 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/strong><span class=\"\"> (HR 0,47)<\/span><span class=\"\">. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd <\/span><strong><span class=\"\">\u03c0\u03c1\u03ce\u03c4\u03b7 \u03c6\u03bf\u03c1\u03ac<\/span><\/strong><span class=\"\"> \u03c0\u03bf\u03c5 \u03ad\u03bd\u03b1 anti-CLDN18.2 ADC \u03b4\u03b5\u03af\u03c7\u03bd\u03b5\u03b9 \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7, \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03c2 \u03bd\u03ad\u03b1 \u03b5\u03bb\u03c0\u03af\u03b4\u03b1 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2<\/span><span class=\"\">.<\/span><\/p>\n<h3><span class=\"\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03af\u03bf\u03c5: \u0394\u03cd\u03bf \u03bd\u03ad\u03b5\u03c2 \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ad\u03c2<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Sacituzumab tirumotecan (Sac-TMT): \u0388\u03bd\u03b1 \u03bd\u03ad\u03bf ADC<\/span><\/strong><\/p>\n<p>\u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 TroFuse-005 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b5 \u03c4\u03bf sacituzumab tirumotecan, \u03ad\u03bd\u03b1 ADC \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c4\u03b7\u03bd TROP2, \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03af\u03bf\u03c5 \u03c0\u03bf\u03c5 \u03b5\u03af\u03c7\u03b1\u03bd \u03ae\u03b4\u03b7 \u03bb\u03ac\u03b2\u03b5\u03b9 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c0\u03bb\u03b1\u03c4\u03af\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03ae\u03c4\u03b1\u03bd \u03b5\u03bd\u03c4\u03c5\u03c0\u03c9\u03c3\u03b9\u03b1\u03ba\u03ac: \u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc 12,1 \u03c3\u03b5 19,0 \u03bc\u03ae\u03bd\u03b5\u03c2 (HR 0,68), \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac 32%, \u03ba\u03b1\u03b9 \u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03b1\u03c0\u03cc 3,9 \u03c3\u03b5 7,2 \u03bc\u03ae\u03bd\u03b5\u03c2 (HR 0,59). \u03a4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c5\u03bd\u03bf\u03b4\u03b5\u03cd\u03c4\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c3\u03c5\u03c7\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c3\u03bf\u03b2\u03b1\u03c1\u03ce\u03bd \u03b1\u03bd\u03b5\u03c0\u03b9\u03b8\u03cd\u03bc\u03b7\u03c4\u03c9\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03b5\u03b9\u03ce\u03bd, \u03b3\u03b5\u03b3\u03bf\u03bd\u03cc\u03c2 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b3\u03c1\u03b1\u03bc\u03bc\u03af\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03b3\u03ba\u03b7 \u03c0\u03c1\u03bf\u03c3\u03b5\u03ba\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03b1\u03ba\u03bf\u03bb\u03bf\u03cd\u03b8\u03b7\u03c3\u03b7\u03c2 \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd.<\/p>\n<p class=\"ds-markdown-paragraph\"><strong><span class=\"\">Pembrolizumab \u03c9\u03c2 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1: \u039c\u03b9\u03b1 \u00ab\u03c7\u03c9\u03c1\u03af\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u00bb \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae<\/span><\/strong><\/p>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">\u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 <\/span><strong><span class=\"\">KEYNOTE-C93<\/span><\/strong><span class=\"\"> \u03c3\u03c5\u03bd\u03ad\u03ba\u03c1\u03b9\u03bd\u03b5 \u03c4\u03b7\u03bd <\/span><strong><span class=\"\">pembrolizumab<\/span><\/strong><span class=\"\"> \u03c9\u03c2 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b1\u03c3\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 (\u03ba\u03b1\u03c1\u03b2\u03bf\u03c0\u03bb\u03b1\u03c4\u03af\u03bd\u03b7 + \u03c0\u03b1\u03ba\u03bb\u03b9\u03c4\u03b1\u03be\u03ad\u03bb\u03b7) \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <\/span><strong><span class=\"\">dMMR<\/span><\/strong><span class=\"\"> (\u03b1\u03bd\u03b5\u03c0\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03bf\u03c5 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03bf\u03cd \u03b5\u03c0\u03b9\u03b4\u03b9\u03cc\u03c1\u03b8\u03c9\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 DNA) \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03ae \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03b9\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b4\u03bf\u03bc\u03b7\u03c4\u03c1\u03af\u03bf\u03c5. \u0397 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03b1\u03c5\u03be\u03ae\u03b8\u03b7\u03ba\u03b5 \u03b1\u03c0\u03cc <\/span><strong><span class=\"\">8,4 \u03c3\u03b5 38,2 \u03bc\u03ae\u03bd\u03b5\u03c2<\/span><\/strong><span class=\"\"> (HR 0,57), \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03ae \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac <\/span><strong><span class=\"\">43%<\/span><\/strong><span class=\"\">. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 <\/span><strong><span class=\"\">\u03b4\u03b5\u03bd \u03c3\u03c5\u03bd\u03ad\u03ba\u03c1\u03b9\u03bd\u03b5<\/span><\/strong><span class=\"\"> \u03c4\u03b7 \u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c3\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03cc \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03bf\u03cd\u03c4\u03b5 \u03b1\u03c0\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c3\u03c4\u03b1\u03c4\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7. \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c5\u03c0\u03bf\u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03bf\u03c5\u03bd \u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 <\/span><strong><span class=\"\">\u03b1\u03c0\u03bf\u03c6\u03c5\u03b3\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2<\/span><\/strong><span class=\"\"> \u03c3\u03b5 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2, \u03c7\u03c9\u03c1\u03af\u03c2 \u03bd\u03b1 \u03c4\u03b5\u03ba\u03bc\u03b7\u03c1\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03b3\u03b5\u03bd\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03b1\u03b8\u03b9\u03b5\u03c1\u03c9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/span><\/p>\n<h3><span class=\"\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2: \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 VOLGA \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b5\u03c1\u03b9\u03b5\u03b3\u03c7\u03b5\u03b9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">\u03a3\u03c4\u03bf\u03bd <\/span><strong><span class=\"\">\u03bc\u03c5\u03bf\u03b4\u03b9\u03b7\u03b8\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03b7\u03c2 \u03bf\u03c5\u03c1\u03bf\u03b4\u03cc\u03c7\u03bf\u03c5 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2<\/span><\/strong><span class=\"\">, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 <\/span><strong><span class=\"\">VOLGA<\/span><\/strong><span class=\"\"> \u03b1\u03bd\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03cc\u03bf\u03b4\u03bf \u03b3\u03b9\u03b1 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c0\u03bf\u03c5 <\/span><strong><span class=\"\">\u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03c3\u03b9\u03c3\u03c0\u03bb\u03b1\u03c4\u03af\u03bd\u03b7<\/span><\/strong><span class=\"\"> \u03ae \u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03b8\u03c5\u03bc\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c4\u03b7 \u03bb\u03ac\u03b2\u03bf\u03c5\u03bd. \u039f \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc\u03c2 <\/span><strong><span class=\"\">enfortumab vedotin + durvalumab<\/span><\/strong><span class=\"\"> \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2, \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2 \u03ae \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac <\/span><strong><span class=\"\">49%<\/span><\/strong><span class=\"\"> \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac <\/span><strong><span class=\"\">42%<\/span><\/strong><span class=\"\"> \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c4\u03b7\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b1\u03c2 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5<\/span><span class=\"\">. \u03a0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1, \u03c4\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc <\/span><strong><span class=\"\">\u03c0\u03bb\u03ae\u03c1\u03bf\u03c5\u03c2 \u03c0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03bf\u03b1\u03bd\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03ae\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2<\/span><\/strong><span class=\"\"> \u03ad\u03c6\u03c4\u03b1\u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03bf <\/span><strong><span class=\"\">45%<\/span><\/strong><span class=\"\">, \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 <\/span><strong><span class=\"\">10%<\/span><\/strong><span class=\"\"> \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5. \u03a0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 <\/span><strong><span class=\"\">\u03b4\u03c5\u03bd\u03b7\u03c4\u03b9\u03ba\u03ac \u03b9\u03ac\u03c3\u03b9\u03bc\u03b7 \u03bd\u03cc\u03c3\u03bf<\/span><\/strong><span class=\"\">, \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03bf\u03c0\u03bf\u03af\u03bf\u03c5\u03c2 \u03bf\u03b9 \u03c0\u03c1\u03bf\u03b5\u03b3\u03c7\u03b5\u03b9\u03c1\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2 \u03ae\u03c4\u03b1\u03bd \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2.<\/span><\/p>\n<h3><span class=\"\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5: \u0397 \u03b4\u03b9\u03c0\u03bb\u03ae \u03b1\u03bd\u03bf\u03c3\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03be\u03af\u03b1 \u03c4\u03b7\u03c2<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">\u03a3\u03c4\u03bf\u03bd <\/span><strong><span class=\"\">\u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5<\/span><\/strong><span class=\"\"> \u03bc\u03b5 <\/span><strong><span class=\"\">MSI-H\/dMMR<\/span><\/strong><span class=\"\">, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 <\/span><strong><span class=\"\">CheckMate 8HW<\/span><\/strong><span class=\"\"> \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b5 \u03c4\u03bf\u03bd \u03c1\u03cc\u03bb\u03bf \u03c4\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03bf\u03cd <\/span><strong><span class=\"\">nivolumab + ipilimumab<\/span><\/strong><span class=\"\">. \u03a3\u03c4\u03b7\u03bd \u03c0\u03c1\u03ce\u03c4\u03b7 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03b7 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 <\/span><strong><span class=\"\">\u03b4\u03b5\u03bd \u03b5\u03c0\u03b9\u03c4\u03b5\u03cd\u03c7\u03b8\u03b7\u03ba\u03b5<\/span><\/strong><span class=\"\"> \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc, \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 <\/span><strong><span class=\"\">50,1 \u03bc\u03b7\u03bd\u03ce\u03bd<\/span><\/strong><span class=\"\"> \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1, \u03bc\u03b5 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac <\/span><strong><span class=\"\">63%<\/span><\/strong><span class=\"\"> (HR 0,37)<\/span><span class=\"\">. \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03b9\u03ce\u03bd\u03bf\u03c5\u03bd \u03cc\u03c4\u03b9 \u03bf <\/span><strong><span class=\"\">\u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03cc\u03c2 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2<\/span><\/strong><span class=\"\"> \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03af\u03c3\u03b5\u03b9 \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c3\u03c4\u03c1\u03b1\u03c4\u03b7\u03b3\u03b9\u03ba\u03ae, \u03c0\u03c1\u03bf\u03c3\u03c6\u03ad\u03c1\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 <\/span><strong><span class=\"\">\u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5<\/span><\/strong><span class=\"\"> \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/span><\/p>\n<h3><span class=\"\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd: \u0397 \u03c1\u03b9\u03bc\u03c0\u03bf\u03c3\u03b9\u03ba\u03bb\u03af\u03bc\u03c0\u03b7 \u00ab\u03ba\u03b5\u03c1\u03b4\u03af\u03b6\u03b5\u03b9\u00bb \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b2\u03ac\u03b8\u03bf\u03c2 \u03c7\u03c1\u03cc\u03bd\u03bf\u03c5<\/span><\/h3>\n<p class=\"ds-markdown-paragraph\"><span class=\"\">\u03a3\u03c4\u03bf\u03bd <\/span><strong><span class=\"\">\u03c0\u03c1\u03ce\u03b9\u03bc\u03bf, \u03bf\u03c1\u03bc\u03bf\u03bd\u03bf\u03b5\u03c5\u03b1\u03af\u03c3\u03b8\u03b7\u03c4\u03bf, HER2-\u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/span><\/strong><span class=\"\"> \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 II \u03ae III, \u03c4\u03b1 <\/span><strong><span class=\"\">\u03b5\u03be\u03b1\u03b5\u03c4\u03ae<\/span><\/strong><span class=\"\"> \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7\u03c2 <\/span><strong><span class=\"\">NATALEE<\/span><\/strong><span class=\"\"> \u03b5\u03c0\u03b9\u03b2\u03b5\u03b2\u03b1\u03af\u03c9\u03c3\u03b1\u03bd \u03c4\u03b7 <\/span><strong><span class=\"\">\u03b4\u03b9\u03b1\u03c4\u03ae\u03c1\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03bf\u03c6\u03ad\u03bb\u03bf\u03c5\u03c2<\/span><\/strong><span class=\"\"> \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 <\/span><strong><span class=\"\">\u03c1\u03b9\u03bc\u03c0\u03bf\u03c3\u03b9\u03ba\u03bb\u03af\u03bc\u03c0\u03b7\u03c2<\/span><\/strong><span class=\"\"> \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03bf\u03c1\u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0397 <\/span><strong><span class=\"\">\u03b5\u03be\u03b1\u03b5\u03c4\u03ae\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7<\/span><\/strong><span class=\"\"> \u03b1\u03bd\u03ae\u03bb\u03b8\u03b5 \u03c3\u03b5 <\/span><strong><span class=\"\">91,9%<\/span><\/strong><span class=\"\"> \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 <\/span><strong><span class=\"\">89,7%<\/span><\/strong><span class=\"\"> \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bf\u03c1\u03bc\u03bf\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03cc\u03bd\u03bf, \u03bc\u03b9\u03b1 <\/span><strong><span class=\"\">\u03b1\u03c0\u03cc\u03bb\u03c5\u03c4\u03b7 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 2,1%<\/span><\/strong><span class=\"\"> \u03ba\u03b1\u03b9 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5 \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac <\/span><strong><span class=\"\">19,1%<\/span><\/strong><span class=\"\">. \u03a4\u03bf \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03bb\u03b7\u03c8\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ce\u03bd <\/span><strong><span class=\"\">\u03b4\u03b9\u03b5\u03c5\u03c1\u03cd\u03bd\u03b8\u03b7\u03ba\u03b5<\/span><\/strong><span class=\"\"> \u03b1\u03c0\u03cc 4,1% \u03c3\u03c4\u03b1 \u03c0\u03ad\u03bd\u03c4\u03b5 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03c3\u03b5 <\/span><strong><span class=\"\">5,3%<\/span><\/strong><span class=\"\"> \u03c3\u03c4\u03b1 \u03ad\u03be\u03b9, \u03b5\u03bd\u03b9\u03c3\u03c7\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 <\/span><strong><span class=\"\">\u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03ae\u03b4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b1 \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1<\/span><\/strong><span class=\"\">.<\/span><\/p>\n<h3><span class=\"\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7: \u039f darolutamide \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03bc\u03b5\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2<\/span><\/h3>\n<p>\u03a3\u03c4\u03bf\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03c0\u03bf\u03bb\u03cd \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 DASL-HiCaP \u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 darolutamide \u03c3\u03c4\u03b7 \u03bc\u03b1\u03ba\u03c1\u03bf\u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03b1\u03bd\u03b4\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ae \u03b1\u03c0\u03bf\u03c3\u03c4\u03ad\u03c1\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2. \u03a4\u03bf \u03c4\u03b5\u03c4\u03c1\u03b1\u03b5\u03c4\u03ad\u03c2 \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03ad\u03c6\u03c4\u03b1\u03c3\u03b5 \u03c4\u03bf 95% \u03bc\u03b5 \u03c4\u03bf darolutamide, \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 88% \u03bc\u03b5 \u03c4\u03bf placebo, \u03bc\u03b5\u03b9\u03ce\u03bd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03bc\u03b5\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ae \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac 58%. \u03a4\u03bf \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03b9 \u03c4\u03b7 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03c4\u03b1\u03c4\u03b9\u03ba\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03c3\u03b5 \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b1 \u03b5\u03c0\u03b9\u03bb\u03b5\u03b3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2, \u03bc\u03b5 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03bc\u03b5\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7\u03c2.<\/p>\n<h3><span class=\"\">\u039c\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1: \u03a4\u03bf \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03bf mRNA \u03b3\u03c1\u03ac\u03c6\u03b5\u03b9 \u03b9\u03c3\u03c4\u03bf\u03c1\u03af\u03b1<\/span><\/h3>\n<p>\u039c\u03af\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03c0\u03b9\u03bf \u03ba\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03b5\u03c2 \u03b5\u03be\u03b5\u03bb\u03af\u03be\u03b5\u03b9\u03c2 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03c3\u03b5 \u03c4\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 INTerpath-001, \u03c3\u03c4\u03b7\u03bd \u03bf\u03c0\u03bf\u03af\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c4\u03bf intismeran autogene, \u03ad\u03bd\u03b1 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03bf \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03bf \u03c4\u03b5\u03c7\u03bd\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 mRNA. \u03a4\u03bf \u03b5\u03bc\u03b2\u03cc\u03bb\u03b9\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b2\u03ac\u03c3\u03b7 \u03c4\u03b1 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03ac\u03b8\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03c9\u03bd \u03bd\u03b5\u03bf\u03b1\u03bd\u03c4\u03b9\u03b3\u03cc\u03bd\u03c9\u03bd. \u0397 \u03c0\u03c1\u03bf\u03c3\u03b8\u03ae\u03ba\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03ba\u03bf\u03c5\u03c1\u03b9\u03ba\u03ae \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 pembrolizumab, \u03bc\u03b5\u03c4\u03ac \u03c4\u03b7 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7 \u03bc\u03b5\u03bb\u03b1\u03bd\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c5\u03c8\u03b7\u03bb\u03bf\u03cd \u03ba\u03b9\u03bd\u03b4\u03cd\u03bd\u03bf\u03c5, \u03bc\u03b5\u03af\u03c9\u03c3\u03b5 \u03c4\u03bf\u03bd \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2 \u03ae \u03b8\u03b1\u03bd\u03ac\u03c4\u03bf\u03c5 \u03ba\u03b1\u03c4\u03ac 42% (HR 0,58). \u03a3\u03c4\u03b1 \u03b4\u03cd\u03bf \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1, \u03c4\u03bf 82,2% \u03c4\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b1\u03bd \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03c0\u03b1\u03c1\u03ad\u03bc\u03b5\u03bd\u03b1\u03bd \u03c7\u03c9\u03c1\u03af\u03c2 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae, \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 70,0% \u03c3\u03c4\u03b7\u03bd \u03bf\u03bc\u03ac\u03b4\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03bb\u03b1\u03b2\u03b5 \u03bc\u03cc\u03bd\u03bf pembrolizumab. \u0391\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03b1\u03bd\u03ce\u03c1\u03b9\u03bc\u03b1, \u03c0\u03c1\u03cc\u03ba\u03b5\u03b9\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b2\u03ae\u03bc\u03b1 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b5\u03bc\u03b2\u03bf\u03bb\u03af\u03c9\u03bd.<\/p>\n<h3><span class=\"\">\u039a\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c7\u03bf\u03bb\u03b7\u03c6\u03cc\u03c1\u03c9\u03bd: \u03a4\u03bf ivonescimab \u03b4\u03b9\u03b5\u03c5\u03c1\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2<\/span><\/h3>\n<p>\u03a3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03c9\u03bd \u03c7\u03bf\u03bb\u03b7\u03c6\u03cc\u03c1\u03c9\u03bd, \u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 HARMONi-GI1 \u03b1\u03bd\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc ivonescimab (\u03ad\u03bd\u03b1 \u03b1\u03bc\u03c6\u03b9\u03b5\u03b9\u03b4\u03b9\u03ba\u03cc \u03b1\u03bd\u03c4\u03af\u03c3\u03c9\u03bc\u03b1 PD-1\/VEGF) \u03ba\u03b1\u03b9 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2. \u0397 \u03b4\u03b9\u03ac\u03bc\u03b5\u03c3\u03b7 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03ae\u03c4\u03b1\u03bd 14,9 \u03bc\u03ae\u03bd\u03b5\u03c2 \u03ad\u03bd\u03b1\u03bd\u03c4\u03b9 12,1 \u03bc\u03b7\u03bd\u03ce\u03bd \u03bc\u03b5 \u03c4\u03bf\u03bd \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc durvalumab \u03ba\u03b1\u03b9 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2. \u0397 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b4\u03b9\u03b5\u03c5\u03c1\u03cd\u03bd\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c3\u03c4\u03cc\u03c7\u03b5\u03c5\u03c3\u03b7\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b5\u03bd\u03cc\u03c2 \u03b2\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03c3\u03b5 \u03bc\u03b9\u03b1 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03c0\u03b5\u03c1\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ad\u03c2.<\/p>\n<h3><span class=\"\">\u0397 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b7 \u03b5\u03b9\u03ba\u03cc\u03bd\u03b1: \u0394\u03cd\u03bf \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b5\u03c2 \u03b5\u03c0\u03b1\u03bd\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2<\/span><\/h3>\n<p>\u03a4\u03bf ESMO 2026 \u03b1\u03bd\u03ad\u03b4\u03b5\u03b9\u03be\u03b5 \u03cc\u03c4\u03b9 \u03b7 \u03c3\u03cd\u03b3\u03c7\u03c1\u03bf\u03bd\u03b7 \u03bf\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03b5\u03be\u03b5\u03bb\u03af\u03c3\u03c3\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03cd\u03bf \u03c0\u03b1\u03c1\u03ac\u03bb\u03bb\u03b7\u03bb\u03b5\u03c2 \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03cd\u03bd\u03c3\u03b5\u03b9\u03c2. \u0391\u03c0\u03cc \u03c4\u03b7 \u03bc\u03af\u03b1 \u03c0\u03bb\u03b5\u03c5\u03c1\u03ac, \u03bd\u03ad\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u2014\u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf tarlatamab, \u03c4\u03bf divarasib \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03bd\u03ad\u03b1 ADC\u2014 \u03b5\u03c0\u03b9\u03c4\u03c5\u03b3\u03c7\u03ac\u03bd\u03bf\u03c5\u03bd \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03bd\u03bf\u03bb\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b9\u03b4\u03b9\u03b1\u03af\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03cc\u03c0\u03c9\u03c2 \u03bf \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5. \u0391\u03c0\u03cc \u03c4\u03b7\u03bd \u03ac\u03bb\u03bb\u03b7, \u03b7 \u03b1\u03be\u03b9\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03ae\u03c2 \u03c0\u03bb\u03b7\u03c1\u03bf\u03c6\u03bf\u03c1\u03af\u03b1\u03c2 \u2014\u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b1\u03bd\u03b1\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03bc\u03bf\u03c1\u03b9\u03b1\u03ba\u03bf\u03cd \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5, \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd \u03b5\u03bc\u03b2\u03bf\u03bb\u03af\u03c9\u03bd\u2014 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c1\u03b9\u03b2\u03ad\u03c3\u03c4\u03b5\u03c1\u03b7 \u03b5\u03c0\u03b9\u03bb\u03bf\u03b3\u03ae \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2, \u03c4\u03b7 \u03bc\u03b5\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc\u03c4\u03b5\u03c1\u03b7 \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ae\u03b4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b1 \u03c0\u03c1\u03ce\u03b9\u03bc\u03b1 \u03c3\u03c4\u03ac\u03b4\u03b9\u03b1.<\/p>\n<p>\u03a0\u03b1\u03c1\u03cc\u03c4\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bd\u03ad\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03ba\u03b1\u03bd\u03bf\u03bd\u03b9\u03c3\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b4\u03b5\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03c3\u03c9\u03bc\u03b1\u03c4\u03c9\u03b8\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03b8\u03b7\u03bc\u03b5\u03c1\u03b9\u03bd\u03ae \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03b1\u03ba\u03c4\u03b9\u03ba\u03ae, \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03b4\u03b7\u03bc\u03b9\u03bf\u03c5\u03c1\u03b3\u03bf\u03cd\u03bd \u03bf\u03c5\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03bf\u03c0\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b3\u03b9\u03b1 \u03bc\u03b9\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae, \u03b5\u03be\u03b1\u03c4\u03bf\u03bc\u03b9\u03ba\u03b5\u03c5\u03bc\u03ad\u03bd\u03b7 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf\u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03bc\u03b5\u03c4\u03ce\u03c0\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5. \u039a\u03b1\u03b9 \u03b1\u03c5\u03c4\u03cc, \u03c3\u03b5 \u03c4\u03b5\u03bb\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03bb\u03c5\u03c3\u03b7, \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bc\u03ad\u03c4\u03c1\u03bf \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c5\u03c7\u03af\u03b1\u03c2.<\/p>\n<\/p><\/div>\n\n<br \/><a href=\"https:\/\/www.zougla.gr\/ygeia\/pa8isis-prolipsi\/esmo-2026-oi-therapeies-pou-allazoun-ton-karkino-apo-to-exatomikevmeno-emvolio-mrna-eos-ta-nea-exypna-farmaka\/\" class=\"google-drive-opener\">\u0394\u03b7\u03bc\u03bf\u03c3\u03b9\u03b5\u03cd\u03c4\u03b7\u03ba\u03b5 !  <\/a> 2026-11-02 12:21:00<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u03a4\u03bf \u03b5\u03c4\u03ae\u03c3\u03b9\u03bf \u03c3\u03c5\u03bd\u03ad\u03b4\u03c1\u03b9\u03bf \u03c4\u03b7\u03c2 \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ae\u03c2 \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 (ESMO 2026), \u03c0\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7 \u039c\u03b1\u03b4\u03c1\u03af\u03c4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 23 \u03ad\u03c9\u03c2 \u03c4\u03b9\u03c2 27 \u039f\u03ba\u03c4\u03c9\u03b2\u03c1\u03af\u03bf\u03c5, \u03b4\u03b5\u03bd \u03ae\u03c4\u03b1\u03bd \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bc\u03b9\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03c5\u03bd\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03cc\u03bd\u03c9\u03bd. \u0389\u03c4\u03b1\u03bd \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03b8\u03b5\u03c9\u03c1\u03af\u03b1 \u03c3\u03c5\u03bd\u03ac\u03bd\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c0\u03bf\u03c5 \u03c4\u03b1 \u03b4\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03b1 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b5\u03c2 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 3 \u03ae\u03c1\u03b8\u03b1\u03bd \u03bd\u03b1 \u03b1\u03c0\u03b1\u03bd\u03c4\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b5\u03c1\u03c9\u03c4\u03ae\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bf\u03c5 &hellip;<\/p>\n","protected":false},"author":3,"featured_media":2639314,"comment_status":"closed","ping_status":"","sticky":false,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"fifu_image_url":"","fifu_image_alt":"","footnotes":""},"categories":[16],"tags":[34573,1418,2895,1110,109,136,334],"class_list":["post-2897598","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ygeia","tag-esmo","tag-1418","tag-2895","tag-1110","tag-109","tag-136","tag-334"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.4 - aioseo.com -->\n\t<meta name=\"description\" content=\"\u03a4\u03bf \u03b5\u03c4\u03ae\u03c3\u03b9\u03bf \u03c3\u03c5\u03bd\u03ad\u03b4\u03c1\u03b9\u03bf \u03c4\u03b7\u03c2 \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ae\u03c2 \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 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\u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 (ESMO 2026), \u03c0\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7 \u039c\u03b1\u03b4\u03c1\u03af\u03c4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 23 \u03ad\u03c9\u03c2 \u03c4\u03b9\u03c2 27 \u039f\u03ba\u03c4\u03c9\u03b2\u03c1\u03af\u03bf\u03c5, \u03b4\u03b5\u03bd \u03ae\u03c4\u03b1\u03bd \u03b1\u03c0\u03bb\u03ce\u03c2 \u03bc\u03b9\u03b1 \u03b1\u03ba\u03cc\u03bc\u03b7 \u03c3\u03c5\u03bd\u03ac\u03bd\u03c4\u03b7\u03c3\u03b7 \u03b5\u03c0\u03b9\u03c3\u03c4\u03b7\u03bc\u03cc\u03bd\u03c9\u03bd. \u0389\u03c4\u03b1\u03bd \u03c4\u03bf \u03c3\u03b7\u03bc\u03b5\u03af\u03bf \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03b8\u03b5\u03c9\u03c1\u03af\u03b1 \u03c3\u03c5\u03bd\u03ac\u03bd\u03c4\u03b7\u03c3\u03b5 \u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae \u03c0\u03c1\u03ac\u03be\u03b7 \u03ba\u03b1\u03b9 \u03cc\u03c0\u03bf\u03c5 \u03c4\u03b1 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name=\"twitter:title\" content=\"ESMO 2026: \u039f\u03b9 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03bb\u03bb\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf - eportal\" \/>\n\t\t<meta name=\"twitter:description\" content=\"\u03a4\u03bf \u03b5\u03c4\u03ae\u03c3\u03b9\u03bf \u03c3\u03c5\u03bd\u03ad\u03b4\u03c1\u03b9\u03bf \u03c4\u03b7\u03c2 \u0395\u03c5\u03c1\u03c9\u03c0\u03b1\u03ca\u03ba\u03ae\u03c2 \u0395\u03c4\u03b1\u03b9\u03c1\u03b5\u03af\u03b1\u03c2 \u03a0\u03b1\u03b8\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae\u03c2 \u039f\u03b3\u03ba\u03bf\u03bb\u03bf\u03b3\u03af\u03b1\u03c2 (ESMO 2026), \u03c0\u03bf\u03c5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03b8\u03b7\u03ba\u03b5 \u03c3\u03c4\u03b7 \u039c\u03b1\u03b4\u03c1\u03af\u03c4\u03b7 \u03b1\u03c0\u03cc \u03c4\u03b9\u03c2 23 \u03ad\u03c9\u03c2 \u03c4\u03b9\u03c2 27 \u039f\u03ba\u03c4\u03c9\u03b2\u03c1\u03af\u03bf\u03c5, 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